Differential Telomerase Expression in Human Primary Intracranial Tumors
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چکیده
منابع مشابه
Telomerase activity in human breast tumors.
BACKGROUND The activity of the ribonucleoprotein enzyme telomerase is not detected in normal somatic cells; thus, with each cell division, the ends of chromosomes consisting of the telomeric repeats TTAGGG progressively erode. The current model gaining support is that telomerase activity in germline and immortal cells maintains telomere length and thus compensates for the "end-replication probl...
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Since telomerase has been recognized as a relevant factor distinguishing cancer cells from normal cells, it has become a very promising target for anti-cancer therapy. A correlation between short telomere length and increased mortality was revealed in many studies. The telomerase expression/activity appears to be one of the most crucial factors to study to improve cancer therapy and prevention....
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Purpose: Telomerase is considered a molecular marker for malignancy. The aim of this study was to determine telomer-ase activity (TA) as a prognostic factor at diagnosis and as a marker for minimal residual disease during therapy and follow up in nonmetastatic Ewing family of tumors (EFT). Patients and Methods: Primary tumor specimens and 97 peripheral blood (PBL) samples from 31 EFT patients w...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 1997
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/107.5.548